Molecular Evolution and Information

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The Genetic Code

The coin code in table 3.1 applies to the four sided coin. The genetic code works in the same way, except instead of words the code specifies amino acids. The coin code groups the results of the coin tosses into groups of three. The genetic code does the same, except the letters are now chemicals. A group of three bases is called a codon. Each codon specifies an amino acid. For example, with the coin code:

TAC-CCA-TAA-AGA-ATC should be translated as follows: The dog is lazy.

but with the genetic code ( see table 3.2)

TAC-CCA-TAA-AGA-ATC should be translated as follows: methionine-glycine- isoleucine-serine.
   
    So the coin code specified words, and the genetic code specifies amino acids. Table 3.2 lists the genetic code, and figure 3.7 shows the process of transcription in which DNA is use to create RNA. Notice that in figure 3.7 the coding DNA strand creates a complementary RNA strand (G is replaced with C, C is replaced with G, T is replaced with A, and A is replaced with a new chemical unique to RNA - uracil or U for short).

Table 3.2: The Genetic Code

DNA Codon

(CODING STRAND)

Corresponding RNA Codons

(Transcription)

Amino Acid

(Translation)

CCA, CCG, CCT, CCC

GGU, GGC, GGA, GGG

glycine

CGA, CGG, CGT, CGC

GCU, GCC, GCA, GCG

alanine

CAA, CAG, CAT, CAC

GUU, GUC, GUA, GUG

valine

GAA, GAG, GAT, AAC,

GAC, AAT

CUU, CUC, CUA, UUG, CUG, UUA

leucine

TAA, TAG, TAT

AUU, AUC, AUA

isoleucine

GGA, GGG, GGT, GGC

CCU, CCC, CCA, CCG

proline

ACC

UGG

tryptophan

AAA, AAG

UUU, UUC

phenylalanine

TAC

AUG

methionine

AGA, AGG, AGT,AGC, TCA, TCG

UCU, UCC, UCA, UCG, AGU, AGC

serine

TGA, TGG, TGT, TGC

ACU, ACC, ACA, ACG

threonine

GAT, GTG

CUA, CAC

histidine

GTT, GTC

CAA, CAG

glutamine

CTT, CTC

GAA, GAG

glutamate

CTA, CTG

GAU, GAC

aspartate

TTA, TTG

AAU, AAC

asparagine

TTT, TTC

AAA, AAG

lysine

ACA, ACG

UGU, UGC

cysteine

ATA, ATG

UAU, UAC

tyrosine

GCA, GCG, GCT, GCC, TCT, TCC

CGU, CGC, CGA, CGG, AGA, AGG

arginine

ATC, ACT, ATT

UAG, UGA, UAA

Stop

 

next: Transcription

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